Oxidative Stress in Substance Use Disorders: Endogenous and Exogenous Mechanisms of Repair

Substance use disorders (SUDs) can be defined as patterns of symptoms caused by the abusive consumption recreational or prescribed substances that an individual continues to despite their negative effects. Oxidative stress is one main pathophysiological processes occasioned SUDs in different brain areas. damage and subsequent deleterious happen because psychoactive drugs, both stimulants depressants. This chapter focuses on associated with depressant such alcohol, opioids, benzodiazepines, effects central nervous system (CNS). We present characteristics later explore endogenous mechanisms repair, neuroglia endocannabinoid system. also examine neuroprotective exogenous phytocannabinoids (e.g., cannabidiol) N-acetylcysteine (NAC), which have shown important roles anti-inflammatory pathways antioxidative cascades, how these molecules potential tools treatment neurological SUDs.